| 分子探针在细胞凋亡检测中的研究进展 |
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| 引用本文： | 唐敏,曾文彬,曹亚.分子探针在细胞凋亡检测中的研究进展[J].中国生物工程杂志,2011,31(6):124-128. |
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| 作者姓名： | 唐敏 曾文彬 曹亚 |
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| 作者单位： | 1. 中南大学肿瘤研究所 长沙 410078;
2. 中南大学药学院 长沙 410013;
3. 中南大学分子影像研究中心 长沙 410078 |
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| 基金项目： | 广东省自然科学基金资助项目(9151008901000050) |
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| 摘 要： | 分子探针应用于细胞凋亡检测具有直观、无创伤和实时动态观察凋亡分子信息的特点,在疾病早期诊断、监测疾病发展进程、评估疾病治疗效果、发展新的治疗方案等方面具有较好的应用前景.综述了近年来靶向细胞凋亡探针的设计、作用机制、应用等相关的研究进展,并根据亲和组件的作用机制对分子探针进行分类介绍.
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| 关 键 词： | 分子影像 分子探针 细胞凋亡 |
| 收稿时间： | 2010-12-07 |
| 修稿时间： | 2011-03-17 |
Progress in Molecular Probe for the Detection of Apoptosis |
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| TANG Min,ZENG Wen-bin,CAO Ya.Progress in Molecular Probe for the Detection of Apoptosis[J].China Biotechnology,2011,31(6):124-128. |
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| Authors: | TANG Min ZENG Wen-bin CAO Ya |
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| Institution: | 1,3(1 Cancer Research Institute,Central South University,Changsha 410078,China)(2 School of Pharmaceutical Sciences,Central South University,Changsha 410013,China)(3 Molecular Imaging Research Center,Central South University,Changsha 410078,China) |
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| Abstract: | The detection and quantification of apoptosis with molecular probes would be desirable to provide clinicians with intuitive, noninvasive and real-time dynamic information, assisting in diagnosing early diseases, monitoring the course of disease, assessing the efficacy of disease treatment and developing new therapeutic strategies. According to related literatures in the past decade, The progresses in the fields of probes design, mechanism of molecular probes and application in the related research areas were summarized. The molecular probes are classified based on the mechanism of affinity components. |
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| Keywords: | Molecular imaging Molecular probe Cell apoptosis |
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