Effects of Dichloroacetate on Brain Pyruvate Dehydrogenase |
| |
| Authors: | Elliot Abemayor Gyula B. Kovachich Niels Haugaard |
| |
| Affiliation: | Department of Pharmacology and Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A. |
| |
| Abstract: | The action of dichloroacetate (DCA) on pyruvate dehydrogenase (PDH) activity of rat brain has been studied in vitro and in vivo. In a crude brain mitochondrial fraction, DCA inhibits PDH kinase and in rat brain slices this compound increases PDH activity and stimulates glucose oxidation. In the whole animal, intraperitoneal injection of DCA causes activation of brain PDH, indicating that this inhibitor crosses the blood-brain barrier. The same treatment with DCA also produced a large increase in heart PDH activity. Further studies of the effects of DCA on the CNS should lead to results of considerable importance. |
| |
| Keywords: | Rat brain Dichloroacetate Pyruvate dehydrogenase Pyruvate dehydrogenase kinase Dichloroacetate effect in vivo Brain glucose oxidation |
| 本文献已被 PubMed 等数据库收录！ |
|
