宫颈液基超薄细胞学检查临床应用价值探讨

目的探讨宫颈液基超薄细胞学检查（Thinp rep cytologic，TCT）和Bethesda系统（TBS）在宫颈病变诊断中的临床价值。方法对3146例本院宫颈疾病就诊者行TCT检查和TBS细胞学分类诊断，对TCT检查异常者进行阴道镜病理检查。结果异常涂片208例（占6．61％），其中不典型鳞状细胞（ASC）68例（2．19％），低度鳞状上皮内瘤变（LSIL）95例（3．02％）高度鳞状上皮内瘤变（HSIL）41例（1．31％）。鳞状细胞癌（SCC）4例（0．12％）。异常细胞涂片30-39岁80例（38．1％），40—49岁55例（26．12％），与其他年龄组比较差异有统计学意义（P〈0．05）。TCT检查与病理检查符合率分别为LSIL81％，HSIL92％，SCC100％，两者比较差异无统计学意义。结论TCT结合TBS应用于宫颈细胞涂片配合阴道镜活检，是筛查和诊断宫颈癌前病变的可靠手段。

Value of Applying Liquid -based Cytology in Cervical Neoplasia

Objective To explore the value of applying liquid - based cytology and diagnostic Bethesda in cervical neoplasia. Methods A total of 3146 cases chosen from 2006 to 2008 at cervix room in the Yu Hang Maternal and Child Health Hospital underwent TCT and TBS cytodiagnosip, dysplasia of cell were vaginoscopy Results 208 out of 3146（6.61% ） had karyomegaly; 68（2.19% ）cases had atypical epithehum ;95（3.02% ）cases had low squamous epithelioma ;41 （ 1.31% ）cases had high squamous epithelioma ,4（0.12% ）case had squamous cell carcinoma. 80cases from the 30 - 39 years old women had karyomegaly, accounting to a high percentage of 38. 1. 55cases for the 40 - 49 years old women. There were obvious difference between the above and the others. TCT had the same pathological report with LSIL 81%, HSIL92%, SCC 100%. There were no obvious difference. Conclusion liquid - based cytology and diagnostic Bethesda in cervical neoplasia were important methods for screening and diagnosing.