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A method for determination of the excretion rate of deoxycorticosterone |
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| Authors: | R L Weinstein B Lai T Xenakis |
| Affiliation: | 1. The State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China;2. Institute of Environment and Health, Institute for Advanced Study, UCAS, Hangzhou 310000, China;1. Laboratory of Integrative Metabolomics, Department of Translational Physiology, Infectiology and Public Health, Ghent University, 9820, Merelbeke, Belgium;2. School of Biological Sciences, Institute for Global Food Security, Queen''s University Belfast, BT9 5DL, Belfast, Northern Ireland, UK |
| Abstract: | A double-isotope dilution derivative method with collection of carbon-14 and tritrum-labeled steroids during gas-liquid chromatography for the estimation of deoxycorticosterone excretion is described. 4-14C-tetrahydrodeoxycorticosterone is used to correct for loss and 3H-acetic anhydride to measure mass. The levels of deoxycorticosterone excretion were similar after periods of varied salt intake but decreased 59% during dexamethasone treatment in normal subjects. |
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