Changes in the rate of DNA replication fork movement during S phase in mammalian cells. |
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Authors: | D Housman J A Huberman |
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Institution: | Department of Biology Massachusetts Institute of Technology Cambridge, Mass. 02139, U.S.A. |
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Abstract: | DNA fiber autoradiography was used to measure the rate of replication fork movement and the size of replication units as a function of time during the S phase of synchronized Chinese hamster ovary cells. The rate of fork movement increased by about threefold from early S to later S phase, with the most dramatic change occurring in the first hour of S phase. On the other hand, the size of replication units did not vary significantly during S phase. |
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