Effect of verapamil, cromoglycate and dimedrol on the survivability of mice in endotoxic shock

The trial has been performed on blocking the potentiation of the lethal action of Sh. Sonnei endotoxin isolated using the agents possessing antiaggregation and antimediator properties--verapamil, cromoglycate and diphenhydramine. It was shown that LD50 of endotoxin increased 2-2.5-fold, provided there were 3 drug injection 1, 4 and 9 hours after endotoxin administration. The survival of mice at 100% level of mortality was also increased 2-2.5-fold. With endotoxin administered together with the first drug injection, the drugs were ineffective. In case endotoxin was administered 3 times at a 4-hour interval prophylactic and therapeutic effects of the drugs and their combinations have been observed.