Advances in the genomics of ticks and tick-borne pathogens |
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| Authors: | Jongejan Frans Nene Vishvanath de la Fuente Jose Pain Arnab Willadsen Peter |
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| Affiliation: | 1. Department of Veterinary Medicine, University of Maryland, College Park, MD, USA;2. Laboratory for Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA;3. Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA;4. Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA;5. Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA;6. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;7. Eunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD, USA;8. Virginia-Maryland College of Veterinary Medicine, College Park, MD, USA |
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| Abstract: | Ticks and the diseases for which they are vectors engage in complex interactions with their mammalian hosts. These interactions involve the developmental processes of tick and pathogen, and interplay between the defensive responses and counter responses of host, tick and pathogen. Understanding these interactions has long been an intractable problem, but progress is now being made thanks to the flood of genomic information on host, tick and pathogen, and the attendant, novel experimental tools that have been generated. Each advance reveals new levels of complexity, but there are encouraging signs that genomics is leading to novel means of parasite control. |
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