Sustained oscillations in a reconstituted enzyme system containing phosphofructokinase and fructose 1,6-bisphosphatase |
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| Authors: | K Eschrich W Schellenberger E Hofmann |
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| Institution: | Laboratoire de Biochimie (Institut National de la Sante et de la Recherche Medicale et Centre National de la Recherche Scientifique), Departement de Recherche Fondamentale, Centre d''Etudes Nucleaires, 38041 Grenoble, France |
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| Abstract: | In a reconstituted open and homogeneous enzyme system containing phosphofructokinase, fructose 1,6-bisphosphatase, pyruvate kinase, adenylate kinase, and glucose-6-phosphate isomerase sustained oscillations could experimentally be generated. The approach is based on a stirred flow-through reaction chamber. The periodic motions of the reactants are mainly caused by the antagonistic allosteric effects of the adenine nucleotides on the activities of the phosphofructokinase and fructose 1,6-bisphosphatase. |
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| Keywords: | To whom all correspondence should be addressed |
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