Cyclic kinetics and mathematical expression of the primary immune response of soluble antigen |
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| Authors: | M. I. Levi K. V. Durikhin N. N. Basova |
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| Affiliation: | 1. Central Control Research Laboratory of the Municipal Disinfection Station, Moscow, U.S.S.R.
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| Abstract: | The cellular activity of an antigen is understood as its power to cause plasma cells to accumulate in the regional lymph node. Two plasma cell units (PCU) is the dose causing one plasma cell addition (as compared with the “background”), whereas 1 PCU causes neither increase nor decrease in plasma cell number in the regional lymph node. Injections of antigen in less than 1 PCU causes plasma cells to decrease in number. Interrelation between antigen and plasma cells changes with time in different regions of the lymphatic system. |
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