Computational optical biopsy |
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Authors: | Li Yi Jiang Ming Wang Ge |
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Institution: | (1) Department of Mathematics, University of Iowa, Iowa City, IA 52242, USA;(2) Bioluminescence Tomography Laboratory, Departments of Radiology and Biomedical Engineering, University of Iowa, Iowa City, IA 52242, USA |
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Abstract: | Optical molecular imaging is based on fluorescence or bioluminescence, and hindered by photon scattering in the tissue, especially
in patient studies. Here we propose a computational optical biopsy (COB) approach to localize and quantify a light source
deep inside a subject. In contrast to existing optical biopsy techniques, our scheme is to collect optical signals directly
from a region of interest along one or multiple biopsy paths in a subject, and then compute features of an underlying light
source distribution. In this paper, we formulate this inverse problem in the framework of diffusion approximation, demonstrate
the solution uniqueness properties in two representative configurations, and obtain analytic solutions for reconstruction
of both optical properties and source parameters. |
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Keywords: | |
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