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Pseudouridine modification in <Emphasis Type="Italic">Caenorhabditis elegans</Emphasis> spliceosomal snRNAs: unique modifications are found in regions involved in snRNA-snRNA interactions
Authors:Email author" target="_blank">Jeffrey?R?PattonEmail author  Richard?W?Padgett
Institution:(1) Department of Pathology and Microbiology, University of South Carolina School of Medicine Columbia, SC 29208, USA;(2) Department of Molecular Biology and Biochemistry and Cancer Institute of New Jersey, Waksman Institute, YRutgers University, Piscataway, NJ 08854, USA
Abstract:

Background  

Pseudouridine (Ψ) is an abundant modified nucleoside in RNA and a number of studies have shown that the presence of Ψ affects RNA structure and function. The positions of Ψ in spliceosomal small nuclear RNAs (snRNAs) have been determined for a number of species but not for the snRNAs from Caenorhabditis elegans (C. elegans), a popular experimental model system of development.
Keywords:
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