| IL-12和支气管哮喘 |
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| 引用本文： | 李美容,王敏. IL-12和支气管哮喘[J]. 生命的化学, 2010, 0(1) |
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| 作者姓名： | 李美容 王敏 |
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| 作者单位： | 三峡大学第一临床医学院、宜昌市中心人民医院; |
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| 摘 要： | 支气管哮喘是一种气道慢性炎症性疾病。越来越多的事实表明,哮喘的发生与内源性IL-12生成不足有关。IL-12无论单独应用还是作为免疫佐剂,均可逆转哮喘动物模型体内Th1/Th2失衡和抑制气道变态反应性炎症。该文综述了IL-12的生物学效应、IL-12与哮喘的关系、IL-12在哮喘治疗中的作用及其应用。
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| 关 键 词： | 支气管哮喘 IL-12 细胞因子 |
IL-12 and bronchial asthma |
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| Mei-Rong Li,Min Wang The First College of Clinical Medical Science,China Three Gorges University,Yichang Central People's Hospital,Yichang ,China. IL-12 and bronchial asthma[J]. Chemistry of Life, 2010, 0(1) |
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| Authors: | Mei-Rong Li Min Wang The First College of Clinical Medical Science China Three Gorges University Yichang Central People's Hospital Yichang China |
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| Affiliation: | Mei-Rong Li,Min Wang The First College of Clinical Medical Science,China Three Gorges University,Yichang Central People's Hospital,Yichang 443003,China |
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| Abstract: | Bronchial asthma is a chronic inflammatory disease of airways.More and more facts have shown that the incidence of asthma is related to insufficient endogenous production of IL-12.Whether alone or as immune adjutants,IL-12 can reverse Th1/Th2 imbalance in body and suppress allergic airway inflammation in animal models of asthma.This review summarized the recent advances in study of the biological effects of IL-12;the relationship between IL-12 and asthma;the role of IL-12;and the application of IL-12 in the... |
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| Keywords: | bronchial asthma IL-12 cytokine |
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