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2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists |
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| Authors: | Hodgetts Kevin J Yoon Taeyoung Huang Jianhua Gulianello Michael Kieltyka Andrzej Primus Renee Brodbeck Robbin De Lombaert Stéphane Doller Darío |
| Affiliation: | Neurogen Corporation, 35NE Industrial Road, Branford, CT 06405, USA. |
| Abstract: | The discovery, synthesis and structure-activity studies of a novel series of 2-arylpyrimidin-4-ones as CRF-1 receptor antagonists is described. These compounds are structurally simple and display appropriate physical properties for CNS agents |
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