| 茶多酚及其儿茶素单体对过氧化氢诱导的线粒体通透性改变孔道开放的影响 |
| |
| 引用本文： | 沈生荣,金超芳,陈子元,曹远林,赵保路. 茶多酚及其儿茶素单体对过氧化氢诱导的线粒体通透性改变孔道开放的影响[J]. 生物化学与生物物理进展, 2001, 28(6): 890-894 |
| |
| 作者姓名： | 沈生荣 金超芳 陈子元 曹远林 赵保路 |
| |
| 作者单位： | 1. 浙江大学农学院,杭州,310029
2. 中国科学院生物物理研究所脑与认知科学研究中心,北京,100101 |
| |
| 基金项目： | 国家自然科学基金资助项目(29935080). |
| |
| 摘 要： | 线粒体是细胞内重要的细胞器，是生成ATP的主要场所.线粒体通透性改变孔道（PT孔道）的开放会引起线粒体许多功能的紊乱而导致细胞死亡.对茶多酚及其单体儿茶素对过氧化氢诱导的线粒体膨胀及膜电势变化过程中PT孔开放的影响进行了研究.实验结果表明茶多酚及其儿茶素单体对PT孔开放的影响显著不同：茶多酚及其主要成分EGCG和ECG能够有效地抑制PT孔道的开放；而ECG，（+）-C和EGC却加速PT孔道的开放过程.从总体效果来看，茶多酚及其单体EGCG和ECG对线粒体的保护作用占主导地位.
|
| 关 键 词： | 茶多酚，线粒体，自由基 |
| 收稿时间： | 2001-03-15 |
| 修稿时间： | 2001-03-15 |
Effects of Green Tea Polyphenols and Catechins on H2O2-induced Mitochondrial Permeability Transition Pore Opening |
| |
| SHEN Sheng-Rong,JIN Chao-Fang,CHEN Zi-Yuan,CAO Yuan-Lin and ZHAO Bao-Lu. Effects of Green Tea Polyphenols and Catechins on H2O2-induced Mitochondrial Permeability Transition Pore Opening[J]. Progress In Biochemistry and Biophysics, 2001, 28(6): 890-894 |
| |
| Authors: | SHEN Sheng-Rong JIN Chao-Fang CHEN Zi-Yuan CAO Yuan-Lin ZHAO Bao-Lu |
| |
| Affiliation: | College of Agriculture and Biotechonology, Zhejiang University, Hangzhou 310029, China;College of Agriculture and Biotechonology, Zhejiang University, Hangzhou 310029, China;College of Agriculture and Biotechonology, Zhejiang University, Hangzhou 310029, China;Laboratory of Visual Information Processing, Center for Brain and Cognitive Sciences, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China;Laboratory of Visual Information Processing, Center for Brain and Cognitive Sciences, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China |
| |
| Abstract: | Mitochondria are important intracellular organelles in which energy is generated. Mitochondrial permeability transition pore (PTP) opening will induce mitochondrial dysfunction, then result in cell death. The study was caried out to investigate the influence of green tea polyphenols (GTPs) and five kinds of catechins on mitochondrial PTP opening. The results showed that GTPs and catechins have obvious and different effects on H2O2-induced mitochondrial PTP opening. GTPs and its major components EGCG, ECG have inhibitory effects on it, while other kinds of catechins, EGC, EC and (+)-C can accelerate the process. The data provide an alternate interpretation of the potent protective function of GTPs, EGCG and ECG. |
| |
| Keywords: | green tea polyphenol mitochondria free radical |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《生物化学与生物物理进展》浏览原始摘要信息 |
|
点击此处可从《生物化学与生物物理进展》下载全文 |
|
