NHC-containing chiral bidentate ligands: synthesis and evaluation in enantioselective copper-catalyzed conjugate addition |
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| Authors: | Clavier Hervé Guillemin Jean-Claude Mauduit Marc |
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| Institution: | UMR CNRS 6226, Sciences Chimiques de Rennes, Ecole Nationale Supérieure de Chimie de Rennes, Av. du Général Leclerc, 35700 Rennes, France. |
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| Abstract: | New chiral phosphine-, thiolate-, mesylate-, and tosylate-containing N-heterocyclic carbene ligands have been synthesized in fair to excellent yield. These bidentate ligands have been evaluated in enantioselective copper-catalyzed conjugate addition to both cyclic and acyclic enones and displayed good catalytic activities and poor to good enantiomeric excesses (up to 80%). |
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| Keywords: | bidentate chiral ligands N‐heterocyclic carbenes asymmetric catalysis conjugate‐addition copper‐catalyzed |
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