Action of chlorhexidine on buddingCandida albicans: Scanning and transmission electron microscopic study |
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Authors: | Dr Hélène Bobichon Philippe Bouchet |
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Institution: | (1) Faculté de Pharmacie, Laboratoire de Biologie Végétale et Cryptogamie, 51 rue Cognacq-Jay, 51096 Reims, Cédex, France |
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Abstract: | Chlorhexidine is widely used as a bacterial drug whose method of action has been well described in bacteria. Its fungicidal properties have been proved. We show here the effects of a sublethal dose of a preparation of digluconate of chlorhexidine on buddingCandida albicans. A fungistatic action is revealed by a decrease in the percentage of budding cells, and two main types of alterations can be observed with transmission electron microscopy (T.E.M.): a loss of cytoplasmic components and a coagulation of nucleoproteins. With scanning electron microscopy (S.E.M.), the cell walls show morphological modifications. |
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Keywords: | chlorhexidine Candida ultrastructure |
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