The biosynthesis of cytochrome P450 by heavy and light rough endoplasmic reticulum of rat liver |
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| Authors: | M B Cooper J A Craft M R Estall B R Rabin |
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| Affiliation: | Department of Biochemistry, University College London, Gower Street London WC1E 6BT, Great Britain |
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| Abstract: | The synthesis of cytochrome P450 by heavy rough endoplasmic reticulum and light rough endoplasmic reticulum has been examined in vitro, using immunochemical techniques. Contrary to previous indications the results show no evidence for preferential segregation of the cytochrome P450 m-RNA and that the presence of mitochondrial protein synthesis accounts for the differences that have previously been reported. |
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