Double-stranded oligonucleotides containing 5-aminomethyl-2'-deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA |
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Authors: | Shibata Aya Ueno Yoshihito Iwata Mari Wakita Haruka Matsuda Akira Kitade Yukio |
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Institution: | Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu, Japan. |
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Abstract: | This Letter describes the synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker. We found that double-stranded antisense oligonucleotides with aminomethyl residues have high affinity for single-stranded DNA or RNA in buffer solutions with and without MgCl(2). Thus, these oligonucleotides would be useful as antisense oligonucleotides for targeting single-stranded RNA through triplex formation. |
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