Development of a polymorphic strain of Plasmodium vivax in monkeys. |
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| Authors: | W E Collins J Sattabongkot R A Wirtz J C Skinner J R Broderson P G Millet C L Morris B B Richardson J Sullivan V K Filipski |
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| Institution: | Division of Parasitic Diseases, Centers for Disease Control, Atlanta, Georgia 30333. |
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| Abstract: | A strain of Plasmodium vivax from Thailand with a polymorphic repeat unit of the circumsporozoite protein was established in Saimiri sciureus boliviensis and 3 species of Aotus monkeys. All 11 attempts to transmit infection via sporozoite inoculation, 4 times to splenectomized S. sciureus boliviensis, 2 times to splenectomized Aotus nancymai, and 5 times to intact Saimiri monkeys, were successful. Anopheles freeborni, Anopheles stephensi, Anopheles dirus, and Anopheles gambiae mosquitoes were infected by feeding on parasitemic blood from a chimpanzee and an Aotus azarae boliviensis monkey. Our results indicate that this strain may be useful in antisporozoite vaccine trials. |
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