A short primer on RNAi: RNA-directed RNA polymerase acts as a key catalyst. |
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| Authors: | K Nishikura |
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| Affiliation: | The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. kazuko@wistar.upenn.edu |
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| Abstract: | One of the many intriguing features of gene silencing by RNA interference is the apparent catalytic nature of the phenomenon. New biochemical and genetic evidence now shows that an RNA-directed RNA polymerase chain reaction, primed by siRNA, amplifies the interference caused by a small amount of "trigger" dsRNA. |
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