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Secretion of flagellin by the LEE-encoded type III secretion system of enteropathogenic Escherichia coli |
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| Authors: | Luminita Badea Scott A Beatson Maria Kaparakis Richard L Ferrero and Elizabeth L Hartland |
| Institution: | (1) Department of Microbiology, Monash University, Melbourne, Victoria, Australia;(2) Department of Microbiology and Immunology, University of Melbourne, Melbourne, Victoria, Australia;(3) School of Molecular and Microbial Sciences, University of Queensland, Brisbane, Queensland, Australia |
| Abstract: | BackgroundEnteropathogenic Escherichia coli (EPEC) is an attaching and effacing (A/E) pathogen that possesses a type III secretion system (T3SS) encoded within the locus of enterocyte effacement (LEE). The LEE is essential for A/E lesion formation and directs the secretion and translocation of multiple LEE-encoded and non-LEE encoded effector proteins into the cytosol of infected cells. In this study we used proteomics to compare proteins exported to the culture supernatant by wild type EPEC E2348/69, a ΔespADB mutant and a ΔescF T3SS mutant. |
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