Whole-genome resequencing of Escherichia coli K-12 MG1655 undergoing short-term laboratory evolution in lactate minimal media reveals flexible selection of adaptive mutations |
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| Authors: | Tom M Conrad Andrew R Joyce M Kenyon Applebee Christian L Barrett Bin Xie Yuan Gao Bernhard Ø Palsson |
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| Affiliation: | (1) Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0332, USA;(2) Department of Bioengineering, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093-0412, USA;(3) Department of Computer Science, Virginia Commonwealth University, 401 West Main Street, Richmond, Virginia 23284-3019, USA;(4) Center for the Study of Biological Complexity, Virginia Commonwealth University, 1000 W. Cary St., Richmond, Virginia 23284-3068, USA |
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| Abstract: | Background Short-term laboratory evolution of bacteria followed by genomic sequencing provides insight into the mechanism of adaptive evolution, such as the number of mutations needed for adaptation, genotype-phenotype relationships, and the reproducibility of adaptive outcomes. |
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