In Vitro and In Vivo Characteristics of a Thermogelling Rectal Delivery System of Etodolac |
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Authors: | Nahla S Barakat |
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Institution: | (1) Department of Pharmaceutics, College of Pharmacy, King Saud University, P. O. box: 22452, 11495 Riyadh, Saudi Arabia |
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Abstract: | Rectal etodolac–Poloxamer gel systems composed of Poloxamer and bioadhesive polymers were developed and evaluated. Hydroxypropylmethyl
cellulose, poly)vinyl) pyrrolidone, methyl cellulose, hydroxyethylcellulose, and carbopol were examined as mucoadhesive polymers.
The characteristics of the rectal gels differed according to the properties of mucoadhesive polymers. The physicochemical
properties such as gelation temperature, gel strength, and bioadhesive force of various formulations were investigated. The
analysis of release mechanism showed that the release of etodolac was proportional to the square root of time, indicating
that etodolac might be released from the suppositories by Fickian diffusion. The anti-inflammatory effect of etodolac–Poloxamer
gel system was also studied in rats. Moreover, liquid suppository of etodolac did not cause any morphological damage to the
rectal tissues. These results suggested that in situ gelling liquid suppository with etodolac and mucoadhesive polymer was a physically safe, convenient, and effective rectal
dosage form for etodolac. |
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Keywords: | |
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