Acupuncture at Both ST25 and ST37 Improves the Pain Threshold of Chronic Visceral Hypersensitivity Rats |
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| Authors: | Hui-Rong Liu Xiao-Mei Wang En-Hua Zhou Yin Shi Na Li Ling-Song Yuan Huan-Gan Wu |
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| Institution: | (1) First Affiliated Hospital of Shantou University Medical College, No. 57, Changping Road, 515041 Shantou, Guangdong Province, People’s Republic of China;(2) Department of Mechanics and Engineering Science, Fudan University, 220 HanDan Road, YangPu District, 200433 Shanghai, People’s Republic of China;(3) Shanghai Institute of Acupuncture-Moxibustion and Meridians, Shanghai University of Traditional Chinese Medicine, 650 South WanPing Road, XuHui District, 200030 Shanghai, People’s Republic of China |
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| Abstract: | Previous studies demonstrated the efficacy of electro-acupuncture (EA) in relieving chronic visceral hypersensitivity (CVH)
in IBS rats. However, ST25 which is a key acupoint for patients with IBS has not been reported in these experiments. Eight
CVH rats were treated by EA at both ST25 and ST37 for 20 min, once daily for seven consecutive days, model rats (n = 8) and normal rats (n = 8) as controls. After the first EA treatment, the abdominal withdrawal reflex scores were investigated to evaluate the
pain threshold. After seven EA treatments, the concentrations of 5-hydroxytryptamine (5-HT), 5-HT3 receptor (5-HT3R) and 5-HT4
receptor (5-HT4R) in colon tissue were assayed quantitatively by enzyme-linked immunosorbent assay. The results showed that
EA improved the pain threshold of CVH rats, reduced the 5-HT concentration and increased the 5-HT4R concentration, but had
no effect on the 5-HT3R concentration. Further studies are needed to optimize the choice of two-matching points for EA in
the treatment of CVH rats. |
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