Mitochondria in early mammalian development |
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| Authors: | Jonathan Van Blerkom |
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| Institution: | 1. Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80302, United States;2. Colorado Reproductive Endocrinology Rose Medical Center, Denver, CO, United States;1. Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350108, PR China;2. Cellular and Developmental Engineering Center, School of Basic Medical Sciences, Fujian Medical University, Fuzhou,Fujian 350108, PR China;1. Reproductive Medicine & Medical Cytogenetics, Centre of Obstetrics and Gynecology, Regional University Hospital and School of Medicine. Picardie University Jules Verne, Amiens, France;2. Fertilys Inc., Laval, Québec QC, Canada;3. Andrology unit, ForteBio Laboratory, Dax, France;4. IVF & Genetics Laboratory, LaboMac, Clinique des Iris, Casablanca, Morocco;1. Center of Reproductive Medicine, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China;2. Key Laboratory of Reproductive Genetics, Zhejiang University, Ministry of Education, Women‘s Reproductive Health Laboratory of Zhejiang, Hangzhou 310006, China;3. Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310006, China;1. SaBio IREC (CSIC-UCLM-JCCM), ETSIAM, 02071 Albacete, Spain;2. Department of Animal Reproduction, INIA, Avda. Puerta de Hierro, Madrid, Spain;3. Medianilla S.L. Finca Las Lomas, Vejer de la Frontera, Cádiz, Spain;1. Department of Animal Production, Fukuoka Agriculture and Forestry Research Center, Yoshiki 1269, Chikushino, Fukuoka, 818-0004, Japan;2. Department of Animal Science, Tokyo University of Agriculture, Funako 1737, Atsugi, Kanagawa, 243-0034, Japan |
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| Abstract: | The role of mitochondria as central determinants of development competence of oocytes and preimplantation stage embryos is considered in the context of the diverse activities these organelles have in normal cell function. Stage- and cell-cycle-specific mitochondrial translocations and redistributions are described with respect to mechanisms of cytoplasmic remodeling that may establish domains of autonomous regulation of mitochondrial function and activity during early development. The functions of mitochondria as intracellular signaling elements, as regulators of signaling pathways, and oxygen sensors in differentiated cells are suggested to have similar capacities during mammalian oogenesis and early embryogenesis. Questions concerning the numerical size of the oocyte mitochondrial complement, the energy required to support normal preovulatory oogenesis and preimplantation embryogenesis, and the regulation of mitochondrial activity by extrinsic and intrinsic factors are addressed with respect the potential they may have for new investigational approaches to study the origin of the differential developmental competence of human oocytes and preimplantation stage embryos. |
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