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Cellular events in nicotine addiction |
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| Authors: | Rachel E. Penton Robin A.J. Lester |
| Affiliation: | 1. Department of Human Anatomy, Cross River University of Technology, Okuku Campus, Cross River, Nigeria;2. Department of Anatomy and Cell Biology, Obafemi Awolowo University, Ile-Ife, Osun, Nigeria;1. Global Exploratory Development, New Medicine, UCB Pharma, Chemin du Foriest, Braine-l’Alleud 1420, Belgium;2. Research and Development, Chief Medical Office, GSK, 5 Moore Drive, PO Box 13398, RTP, NC 27709-3398, USA;3. Global Research & Development, Reckitt Benckiser Pharmaceuticals Inc., 10710 Midlothian Turnpike Suite 430, Richmond, VA 23235, USA |
| Abstract: | In the 25 years since the observation that chronic exposure to nicotine could regulate the number and function of high affinity nicotine binding sites in the brain there has been a major effort to link alterations in nicotinic acetylcholine receptors (nAChRs) to nicotine-induced behaviors that drive the addiction to tobacco products. Here we review the proposed roles of various nAChR subtypes in the addiction process, with emphasis on how they are regulated by nicotine and the implications for understanding the cellular neurobiology of addiction to this drug. |
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