Nuclear pore proteins and cancer |
| |
Authors: | Songli Xu Maureen A. Powers |
| |
Affiliation: | 1. Abteilung für Molekulare Strukturbiologie, Institut für Mikrobiologie und Genetik, Göttinger Zentrum für Molekulare Biowissenschaften, Georg-August-Universität Göttingen, Göttingen, Germany;2. Department of Molecular Biology, Faculty of Medicine, Georg-August-University of Göttingen, Göttingen, Germany;3. Institute of Molecular Biology and Medicine, Université Libre de Bruxelles, Charleroi, Belgium |
| |
Abstract: | Nucleocytoplasmic trafficking of macromolecules, a highly specific and tightly regulated process, occurs exclusively through the nuclear pore complex. This immense structure is assembled from approximately 30 proteins, termed nucleoporins. Here we discuss the four nucleoporins that have been linked to cancers, either through elevated expression in tumors (Nup88) or through involvement in chromosomal translocations that encode chimeric fusion proteins (Tpr, Nup98, Nup214). In each case we consider the normal function of the nucleoporin and its translocation partners, as well as what is known about their mechanistic contributions to carcinogenesis, particularly in leukemias. Studies of nucleoporin-linked cancers have revealed novel mechanisms of oncogenesis and in the future, should continue to expand our understanding of cancer biology. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|