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Studies on α(1→5) linked octyl arabinofuranosyl disaccharides for mycobacterial arabinosyl transferase activity |
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| Authors: | Ashish K Pathak Vibha Pathak Joseph A Maddry William J Suling Sudagar S Gurcha Gurdyal S Besra Robert C Reynolds |
| Institution: | a Department of Organic Chemistry, Southern Research Institute, PO Box 55305, Birmingham, AL 35255, USA;b Department of Microbiology, Southern Research Institute, PO Box 55305, Birmingham, AL 35255, USA;c The School of Microbiological, Immunological & Virological Sciences, The University of Newcastle upon Tyne, The Medical School, Framlington Place, Newcastle upon Tyne NE2 4HH, UK |
| Abstract: | The appearance multi-drug resistant Mycobacterium tuberculosis (MTB) throughout the world has prompted a search for new, safer and more active agents against tuberculosis. Based on studies of the biosynthesis of mycobacterial cell wall polysaccharides, octyl 5-O-(α- -arabinofuranosyl)-α- -arabinofuranoside analogues were synthesized and evaluated as inhibitors for M. tuberculosis and Mycobacterium avium. A cell free assay system has been used for the evaluation of these disaccharides as substrates for mycobacterial arabinosyltransferase activity. |
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