Decreased Glucagon-Like Peptide-1 Receptor Immunoreactivity in the Dentate Granule Cell Layer from Adult in the Gerbil Hippocampus |
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| Authors: | Choong Hyun Lee Ki-Yeon Yoo Pan Dong Ryu Joon Ha Park Jung Hoon Choi Sookon Kim In Koo Hwang Young-Myeong Kim Moo-Ho Won |
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| Affiliation: | (1) Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(2) Department of Neurobiology, School of Medicine, and Medical & Bio-Material Research Center, Kangwon National University, Chuncheon, 200-701, South Korea;(3) Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(4) Department of Radiation Oncology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(5) Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(6) Vascular System Research Center and Department of Molecular and Cellular Biochemistry, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea;(7) Institute of Medical Sciences, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea; |
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| Abstract: | In this study, we investigated age-related changes in glucagon-like peptide-1 receptor (GLP-1R) immunoreactivity and its protein levels in the gerbil hippocampus during normal aging. In the postnatal month 3 (PM 3) group, GLP-1R immunoreaction was well observed in neurons, especially pyramidal and non-pyramidal cells in the hippocampus proper, and granule and polymorphic cells in the dentate gyrus. In the hippocampus proper, GLP-1R immunoreactivity in neurons was maintained until PM 24. In the dentate gyrus, however, GLP-1R immunoreactivity in granule cells, not polymorphic cells, was hardly detected from PM 6. Western blot analysis also showed that age-dependent change patterns in GLP-1R protein levels in the gerbil hippocampus were similar to the immunohistochemical changes. These results indicate that GLP-1R immunoreactivity was markedly decreased in dentate granule cells from PM 6, showing that GLP-1R immunoreactivity and its protein levels were decreased in the adult and aged gerbil hippocampus. |
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