Modulation of the progesterone receptor in the fetal uterus of the progesterone-primed guinea pig in vivo and in organ culture |
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| Authors: | C Sumida C Gelly J R Pasqualini |
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| Affiliation: | 1. Department of Chemical and Surfactants Technology, Institute of Advanced Chemistry of Catalonia, IQAC-CSIC, Jordi Girona 18-26, 08034 Barcelona, Spain;2. Laboratory of Microbiocides Chemistry, Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89b, 61-614 Poznań, Poland;2. US Hereditary Angioedema Association, Fairfax, Virginia;3. Medicine Service, Veterans Administration Healthcare, San Diego, California;1. Chemistry Faculty and LG-MSU Joint Laboratory of M.V. Lomonosov Moscow State University, 119991 Moscow, Russia;2. Facultad de Química, Universidad Nacional Autónoma de México, 04510 México D.F., Mexico |
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| Abstract: | Guinea pig fetuses were treated with progesterone for 7 days before placing fetal uteri in organ culture to see if progesterone pre-treatment of fetuses in utero would permanently inhibit the spontaneous rise in progesterone receptor which occurs in organ culture. The data show that: the basal level of progesterone receptor in fetal uteri was not affected by the progesterone treatment and progesterone receptor concentrations in vitro were also not inhibited. When guinea pig fetuses were treated sequentially with progesterone and estradiol, estradiol failed to provoke an uterotrophic effect but it retained its ability to stimulate progesterone receptor concentrations. |
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