Interactions of a new antimitotic agent, NSC-181928, with purified tubulin |
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Authors: | E Hamel C M Lin |
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Affiliation: | Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pa. 15213 USA |
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Abstract: | A series of biochemical analyses were carried out with keratoconus and normal corneas to determine the amount of stromal collagen, degree of posttranslational modification of collagen and the solubility of collagen. Our results revealed there was no obvious alteration in the degree of posttranslational modification of collagen in keratoconus corneas. However, the amount of collagen decreases and solubility of collagen increases in keratoconus corneas. It was also found that keratoconus corneas in organ culture produce substantially more collagenase and gelatinase activities than normal corneas. Our results suggest that keratoconus may represent a collagenolytic disease. |
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Keywords: | To whom reprint requests should be addressed. Present address Department of Ophthalmology University of Cincinnati College of Medicine Cincinnati Ohio 45267. |
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