SSCP analysis of the tyrosine kinase domain of the insulin receptor gene: Polymorphisms detected in South African black and white subjects |
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| Authors: | Vanessa R. Panz Paul Ruff Barry I. Joffe Mary-Anne Kedda Harold C. Seftel |
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| Affiliation: | (1) Carbohydrate and Lipid Metabolism Research Group, Department of Medicine, University of the Witwatersrand Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa, Tel.: (02711) 488-3542; Fax: (02711) 643-4318, ZA;(2) Division of Clinical Haematology and Medical Oncology, University of the Witwatersrand Medical School, Johannesburg, South Africa, ZA;(3) Molecular Hepatology Research Unit, Department of Medicine, University of the Witwatersrand Medical School, Johannesburg, South Africa, ZA |
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| Abstract: | The frequency of DNA polymorphisms in the tyrosine kinase domain (exons 17–21) of the insulin receptor gene was assessed in 30 black and 30 white South Africans, using single-stranded conformation polymorphism and direct sequencing analysis. A comparison of the frequencies of the normal versus the combined polymorphic alleles, found only in exon 17, showed a significant difference between black and white groups (P = 0.037). Received: 25 May 1995 / Revised: 1 September 1995 |
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