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A counterintuitive Mg2+-dependent and modification-assisted functional folding of mitochondrial tRNAs
Authors:Jones Christopher I  Spencer Angela C  Hsu Jennifer L  Spremulli Linda L  Martinis Susan A  DeRider Michele  Agris Paul F
Institution:Department of Structural and Molecular Biology, 128 Polk Hall, Campus Box 7622, North Carolina State University, Raleigh, NC 27695-7622, USA.
Abstract:
Keywords:AAS  amino acid accepting stem  ASL  anticodon stem and loop domain  DSL  dihydrouridine (D) stem and loop domain  D:T complex  folding interaction of the D-half molecule with the T-half molecule  LeuRS  E  coli leucyl-tRNA synthetase  Kd  dissociation constant  LeuRSmt  mitochondrial leucyl-tRNA synthetase  bmtRNAMet  bovine mitochondrial methionine tRNA  ymtRNALeu-ΔACVL  yeast mitochondrial leucine tRNA lacking the anticodon and variable loop domains  tRNALeu1-ΔACVL  E  coli leucine tRNA lacking the anticodon and variable loop domains  MetRSmt  mitochondrial methionyl-tRNA synthetase  Ψ  pseudouridine  TSL  ribothymidine stem and loop domain  VSL  variable stem and loop domain
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