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Redistribution and unmasking of Annexin V binding sites in apoptotic Raji cells |
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| Authors: | di Certo Maria Grazia Faggioni Alberto Barile Giuseppe |
| Affiliation: | Istituto di Biologia e Patologia Molecolare, CNR, V.le Marx 43, Rome 00137, Italy. |
| Abstract: | The complement receptor type 2 (CR2) associates with other surface antigens and proteins and its redistribution and/or unmasking occurs through still unknown mechanism(s). The data presented demonstrate that high-density cultured CR2-positive cells undergo apoptosis and that the redistribution and unmasking of Annexin V binding sites occurs in a fashion similar to the redistribution and unmasking of CR2. Therefore, apoptotic and non apoptotic cells from the same lineage may share a similar mechanism for the exposition of neo-surface markers |
| Keywords: | Cell density‐dependent apoptosis CR2‐positive cells CR2 Anti‐CR2 MoAb Annexin v MoAb Redistribution and unmasking of CR2 and Annexin V binding sites |
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