The direction of opiodid agonists towards mu-, delta- and epsilon-receptors in the vas deferens of the mouse and the rat |
| |
Authors: | M Wüster R Schulz A Herz |
| |
Institution: | Department of Neuropharmacology, Max-Planck-Institut für Psychiatrie, Kraepelinstrasse 2, D-8000 München 40, Federal Republic of Germany |
| |
Abstract: | Chronic treatment of mice with specific opioids results in the development of tolerance of particular opiate receptors in the mouse vas deferens (MVD). Accordingly, the infusion of animals with the specific δ-receptor ligand D-Ala2,D-Leu5]-enkephalin (DADL) or the potent μ-agonist sufentanyl (SUF) produces MVD highly tolerant to δ- and μ-agonists, respectively. Investigating a series of opioids in these preparations provides unequivocal evidence for the simultaneous existence of δ- and μ-receptors in the MVD. Thus, the possibility exists to obtain vasa deferentia, which almost exclusively contain either μ- or δ-opiate receptors. In combination with the rat vas deferens (RVD), a supposedly selective ε-receptor preparation, useful tools are provided for the classification of opioids according to their preference for the μ-, δ- and ε-type of the opiate receptors. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|