A hydroxymethylglutaryl-CoA reductase inhibitor synthesized by yeasts |
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| Authors: | Nina Gunde-Cimerman Ana Plemenita&#; Aleksa Cimerman |
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| Institution: | National Institute of Chemisty, Hajdrihova 19, P.O. Box 30, 61115 Ljubljana, Slovenia; Institute of Biochemistry, Medical Faculty, University of Ljubljana, Vrazov trg2, 61000 Ljubljana, Slovenia |
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| Abstract: | Abstract Screening of different yeast species showed that they are able to synthesize hydroxymethylglutaryl-CoA (HMGCoA) reductase inhibitors. Crude methanol extracts and the purified inhibitors from Pichia labacensis and Candida cariosilignicola were tested for their biological activity on the solubilized microsomal HMGCoA reductase from Chinese hamster ovary cells. Identification of the inhibitors was studied by thin layer chromatography, high pressure liquid chromatography and mass spectroscopy. |
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| Keywords: | Yeasts Pichia labacensis Candida cariosilignicola Inhibition of HMGCoA reductase |
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