Exploratory Analysis on the Use of Statins with or without n-3 PUFA and Major Events in Patients Discharged for Acute Myocardial Infarction: An Observational Retrospective Study |
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| Authors: | Alejandro Macchia Marilena Romero Antonio D’Ettorre Gianni Tognoni Javier Mariani |
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| Affiliation: | 1Laboratory of Pharmacoepidemiology, Consorzio Mario Negri Sud, Santa Maria Imbaro, Chieti, Italy;2GESICA (Grupo de Estudio de Investigación Clínica en Argentina) Foundation, Buenos Aires, Argentina;Consorzio Mario Negri Sud, Italy |
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| Abstract: | BackgroundCombined treatment (CT) with statins and polyunsaturated fatty acids (n-3 PUFA) resulted in a reduction of death and major cardiovascular events when administered after a myocardial infarction (MI). However, recent data suggests that CT may be ineffective because patients are currently treated aggressively and the risk may not be further decreased. We aimed to study the prevalence and the results on major outcomes with CT among patients discharged with a MI in Italy.Conclusions/SignificanceAmong a representative sample of patients discharged with MI in Italy, we observed clinically significant synergism between the effects of statins and n-3 PUFA for most cardiovascular outcomes, including all cause mortality. |
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