Hepatotoxic effects of tert-butyl hydroperoxide (t-BHP) and protection by antioxidants |
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| Authors: | Singh Sangram Mehrotra Sudhir Pandey Rajeev Sandhir Rajat |
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| Institution: | Department of Biochemistry, Dr. R. M. L. Avadh University, Faizabad 224 001, India. |
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| Abstract: | t-BHP induced oxidative stress and Ca2+ function impairment in fresh hepatocytes was studied in order to understand its role in cytotoxicity. Viability of hepatocytes by the release of lactate dehydrogenase and methyl thiazoletetrazolium reduction method alongwith malondialdehyde formation indicated oxidative stress in the hepatotoxic action of t-BHP. |
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