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Primary cortical brain cells influence osteoblast activity |
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| Authors: | Lucas Anissian Michael Kirby |
| Institution: | a Department of Orthopaedic Surgery, Louisiana State University Health Sciences Center, Shreveport, LA, USA b Department of Pediatrics, Pathology and Human Anatomy, Neurosurgery, Loma Linda University, CA, USA c Department of Orthopaedic Surgery, Karolinska University Hospital, Stockholm, Sweden |
| Abstract: | The presence of neuropeptides and neuroreceptors in the bone have been reported in several studies. Bone turn-over seems to be controlled by the nervous system. The actual pathway or the control mechanism is still under investigation. In this study we investigate the changes in osteoblast cells if they are in co-culture with primary cortical brain cells. After seven days in co-culture with the primary fetal brain cells the osteoblast cells exhibited hypertrophic morphological changes and showed stronger ALP activity. |
| Keywords: | Osteoblast Bone turn-over Brain cells Fracture healing |
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