Functional association between influenza A (H1N1) virus and human |
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Authors: | Tao Huang WeiRen Cui LeLe Hu TieQiao Wen Yixue Li Yudong Cai |
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Institution: | a Key Laboratory of Systems Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China b Shanghai Center for Bioinformation Technology, Shanghai 200235, PR China c Institute of Systems Biology, Shanghai University, Shanghai 200444, PR China d School of Life Sciences, Shanghai University, Shanghai 200444, PR china |
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Abstract: | Influenza A (H1N1) virus is a severe threat worldwide. It is important to gain a better understanding of the mechanism of the infection. In the paper, we established a computational framework to investigate the crosstalk between the virus and the host, by finding out the proteins that the virus is attacking. The targeted proteins were predicted by taking human proteins laid on the same GO functions or processes as the virus proteins. One hundred and one core proteins were identified. The results provide some knowledge of the possible biological processes and molecular interactions caused by the viral infection, including the host responses. |
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Keywords: | Influenza A (H1N1) virus Virus-host interaction Functional association network |
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