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Rutecarpine ameliorates bodyweight gain through the inhibition of orexigenic neuropeptides NPY and AgRP in mice |
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| Authors: | Su-Jin Kim Sanghyun Lee Man-Deuk Han Kung-Woo Nam |
| Institution: | a Jung San Bio Technology, Dukjel-Ri, Jeongnam-Myun, Hwaseong-City, Kyunggi-Do 445-964, Republic of Korea b Department of Animal Biotechnology, Kangwon National University, Chuncheon 200-701, Republic of Korea c Department of Applied Plant Science, Chung-Ang University, Anseong 456-756, Republic of Korea d Herbal Quality Control Center, Korea Institute of Oriental Medicine, 488 Expo, Daejeon 305-811, Republic of Korea e Department of Biology, Soonchunhyang University, Asan-City, Chungnam 350-646, Republic of Korea f Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea |
| Abstract: | Orexigenic neuropeptides NPY and AgRP play major roles in feeding and are closely related to obesity and diabetic metabolic syndrome. This study explored the inhibitory effect of rutecarpine on feeding and obesity in high-fat-diet-induced (C57BL/6) and leptin-deficient (ob/ob) obese mice. Both mice strains developed obesity, but the obesity was inhibited by the reduced food intake resulting from rutecarpine treatment (0.01%, p < 0.01). Blood cholesterol, non-fasting glucose, insulin, and leptin levels were reduced, compared with the control group. Rutecarpine inhibited the expression of NPY and AgRP in the arcuate nucleus (ARC) of the hypothalamus and suppressed the expression of both neuropeptides in N29-4 neuronal cells. These results indicate that rutecarpine ameliorates obesity by inhibiting food intake, which involves inhibited expression of the orexigenic neuropeptides NPY and AgRP. |
| Keywords: | Rutecarpine Obesity Orexigenic NPY AgRP |
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