A meta-analysis of HLA-DR polymorphism and genetic susceptibility to idiopathic dilated cardiomyopathy |
| |
Authors: | Bo Jin Xin-Ping Luo Huan-Chun Ni Wei Shen Hai-Ming Shi Yong Li |
| |
Institution: | (1) Department of Cardiology, Huashan Hospital, Fudan University, 12 Middle Urumqi Road, Shanghai, 200040, China; |
| |
Abstract: | Idiopathic dilated cardiomyopathy (IDC) has been hypothesized as a multifactorial disorder initiated by an environment trigger
in individuals with predisposing human leukocyte antigen (HLA) alleles. Published data on the association between HLA-DR polymorphism
and IDC risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total
of 19 case–control studies including 1,378 cases and 10,383 controls provided data on the association between HLA-DR polymorphism
and genetic susceptibility to IDC. Overall, statistically elevated frequencies of HLA-DR4 (OR 1.58; 95% CI 1.21–2.07; P = 0.0009) and HLA-DR5 (OR 1.35; 95% CI 1.05–1.73; P = 0.02) alleles were found in patients with IDC compared with controls. Individuals with HLA-DR3 antigen have a protective
effect against IDC (OR 0.72; 95% CI 0.58–0.90; P = 0.004). In summary, this meta-analysis indicated that certain HLA-DR alleles may be genetic markers for susceptibility
and resistance to IDC. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|