In Vivo Synergy Between Green Tea Extract and Levofloxacin Against Enterohemorrhagic Escherichia coli O157 Infection |
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| Authors: | Emiko Isogai Hiroshi Isogai Kimiharu Hirose Shunji Hayashi Keiji Oguma |
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| Institution: | (1) Dept. of Preventive Dentistry, Health Sciences Univ. of Hokkaido, Ishikari-Tobetsu 1757, Hokkaido 061-0293, Japan, JP;(2) Division of Animal Experimentation, Sapporo Medical University, Minami 1, Nishi 16, Sapporo 060-8556, Japan, JP;(3) Dept. of Microbiology, Jichi Medical Univ., Yakushiji 3311, Kawati, Totigi 329-0498, Japan, JP;(4) Dept. of Bacteriology, Okayama University Medical School, Okayama, Okayama 700-8558, Japan, JP |
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| Abstract: | We studied the synergistic effects of Japanese green tea extract (JGTE) and levofloxacin (LVFX) against enterohemorrhagic
Escherichia coli (EHEC) infection in a gnotobiotic mouse model. Mice fed on JGTE conferred a significant degree of protection against an oral
challenge with EHEC. Complete elimination of the bacteria from the mice, was however, difficult. The combination of JGTE and
LVFX increased the survival rate and reduced damage to target organs. Thus, dietary supplementation with JGTE improved the
therapeutic effects of antibiotic treatment.
Received: 28 July 2000 / Accepted: 19 September 2000 |
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