Independent Isolates of the Emerging Subgroup J Avian Leukosis Virus Derive from a Common Ancestor |
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| Authors: | Scott J Benson Brian L Ruis Amy L Garbers Aly M Fadly and Kathleen F Conklin |
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| Institution: | Department of Biochemistry, Molecular Biology and Biophysics,1. Department of Microbiology,4. and the Institute of Human Genetics,2. University of Minnesota Medical School, Minneapolis, Minnesota 55455, and Avian Disease and Oncology Laboratory, USDA Agricultural Research Service, East Lansing, Michigan 488233. |
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| Abstract: | A new subgroup of avian leukosis virus (ALV) that includes a unique env gene, designated J, was identified recently in England. Sequence analysis of prototype English isolate HPRS-103 revealed several other unique genetic characteristics of this strain and provided information that it arose by recombination between exogenous and endogenous virus sequences. In the past several years, ALV J type viruses (ALV-J) have been isolated from broiler breeder flocks in the United States. We were interested in determining the relationship between the U.S. and English isolates of ALV-J. Based on sequence data from two independently derived U.S. field isolates, we conclude that the U.S. and English isolates of ALV-J derive from a common ancestor and are not the result of independent recombination events. |
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