Practical, asymmetric synthesis of 16-hydroxyeicosa-5(Z),8(Z), 11(Z),14(Z)-tetraenoic acid (16-HETE), an endogenous inhibitor of neutrophil activity |
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| Authors: | Reddy Y Krishna Reddy L Manmohan Capdevila Jorge H Falck J R |
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| Affiliation: | Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038, USA. |
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| Abstract: | An asymmetric synthesis of 16-HETE, an endogenous inhibitor of neutrophil activity, was achieved in six steps from R-(-)-glycidyl benzyl ether in 28% overall yield. |
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