| 心肌细胞兴奋收缩耦联的分子机制 |
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| 引用本文： | 王世强,杨华乾. 心肌细胞兴奋收缩耦联的分子机制[J]. 中国科学:生命科学, 2013, 0(10): 833-841 |
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| 作者姓名： | 王世强 杨华乾 |
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| 作者单位： | 北京大学生命科学学院,生物膜与膜生物工程国家重点实验室,北京100871 |
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| 基金项目： | 国家重点基础研究发展计划（批准号：2011CB809101）和国家自然科学基金（批准号：81370203）资助项目 |
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| 摘 要： | 肌细胞兴奋时，动作电位通过电压门控钙通道激活肌质网钙释放，由此引发的细胞内钙离子的瞬时升高驱动细胞收缩，这个过程叫做兴奋收缩耦联．21世纪以来，随着钙成像技术和分子细胞生物学技术的联合应用，心肌兴奋收缩耦联的分子机制逐步阐明．本文结合本实验室的相关研究，系统总结该领域的前沿进展，包括钙释放通道的分子性质、电压门控钙通道激活肌质网钙释放通道的动力学过程、生理调控以及病理变化．
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| 关 键 词： | 心肌细胞 兴奋收缩耦联 钙信号 钙通道 肾上腺素受体 心力衰竭 |
Molecular Mechanisms of Excitation-Contraction in Heart Cells |
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| WANG ShiQiang ＆ YANG HuaQian. Molecular Mechanisms of Excitation-Contraction in Heart Cells[J]. Scientia Sinica Vitae, 2013, 0(10): 833-841 |
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| Authors: | WANG ShiQiang ＆ YANG HuaQian |
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| Affiliation: | WANG ShiQiang ＆ YANG HuaQian State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China |
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| Abstract: | During myocyte excitation, the action potential activates voltage-gated calcium channels, which in turn activate the calcium release from the sarcoplasmic reticulum. The resultant calcium transient drives the contraction of the cell. This process is known as excitation-contraction coupling. In the past years of this new century, the molecular mechanisms of excitation-contraction has been revealed by combining calcium imaging technology with molecular and cellular assays. Based on the work from our lab and literatures, this review systemically summarizes the recent advances in this field, including the molecular behavior of calcium release channels, as well as the kinetics, physiological regulations and pathological modifications of its activation by voltage-gated calcium channels. |
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| Keywords: | cardiomyocyte excitation-contraction coupling calcium signal calcium channel adrenergic receptor heart failure |
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