A non-sense mutation in the putative anti-mutator gene <Emphasis Type="Italic">ada/alkA</Emphasis> of <Emphasis Type="Italic">Mycobacterium tuberculosis</Emphasis> and <Emphasis Type="Italic">M. bovis</Emphasis> isolates suggests convergent evolution |
| |
Authors: | Laurent X Nouvel Tiago Dos Vultos Eric Kassa-Kelembho Jean Rauzier Brigitte Gicquel |
| |
Institution: | 1.Unité de Génétique Mycobactérienne,,Institut Pasteur,Paris Cedex,France;2.Laboratoire des Mycobactéries,Institut Pasteur,Bangui,Central African Republic |
| |
Abstract: | Background Previous studies have suggested that variations in DNA repair genes of W-Beijing strains may have led to transient mutator
phenotypes which in turn may have contributed to host adaptation of this strain family. Single nucleotide polymorphism (SNP)
in the DNA repair gene mutT1 was identified in MDR-prone strains from the Central African Republic. A Mycobacteriumtuberculosis H37Rv mutant inactivated in two DNA repair genes, namely ada/alkA and ogt, was shown to display a hypermutator phenotype. We then looked for polymorphisms in these genes in Central African Republic
strains (CAR). |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|