Parvalbumin Immunoreactivity and Protein Level are Altered in the Gerbil Hippocampus During Normal Aging |
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Authors: | Choong Hyun Lee In Koo Hwang Ki-Yeon Yoo Jung Hoon Choi Ok Kyu Park In Se Lee Moo-Ho Won |
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Institution: | (1) Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea;(2) Department of Anatomy and Neurobiology, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea;(3) Institute of Neurodegeneration and Neuroregeneration, College of Medicine, Hallym University, Chuncheon, 200-702, South Korea |
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Abstract: | Hippocampal interneurons are local circuit neurons which are responsible for inhibitory activity in the hippocampus. Parvalbumin
(PV) is one of useful markers for GABAergic interneurons, not for principle cells, in the hippocampus. In the present study,
we investigated age-related changes in PV immunoreactive neurons and protein levels in the gerbil hippocampus during normal
aging. PV immunoreactive neurons were detected in all hippocampal subregions of all groups. PV immunoreactive neurons, which
innervated principal neurons, were non-pyramidal neurons in the hippocampal CA1-3 regions, and were polymorphic neurons in
the dentate gyrus. In the hippocampal CA1 region, the number of PV immunoreactive neurons was significantly reduced in the
postnatal month 3 (PM 3) group, which was sustained by PM 18, and, at PM 24, the number of PV immunoreactive neurons was significantly
decreased. In the CA2/3 region and dentate gyrus, the number of PV immunoreactive neurons was significantly decreased at PM
6: Thereafter, the number of PV immunoreactive neurons was sustained until PM 24. In addition, changes in PV protein levels
in the gerbil hippocampus were similar to immunohistochemical changes during normal aging: PV protein levels were significantly
decreased with age by PM 6: Thereafter, PV protein levels were sustained by PM 24. These results suggest that PV immunoreactive
interneurons were decreased in the hippocampus with age in gerbils. |
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Keywords: | Parvalbumin Aging CA1-3 regions Dentate gyrus Non-pyramidal neurons Polymorphic cells |
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