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生物标记物与精准医疗研究进展
引用本文:蒋析文,董子维,刘悦,朱小亚.生物标记物与精准医疗研究进展[J].中国生物工程杂志,2019,39(2):74-81.
作者姓名:蒋析文  董子维  刘悦  朱小亚
作者单位:中山大学达安基因股份有限公司 广州 510665
摘    要:自2015年精准医疗理念提出后,生物标记物与精准医疗愈加被人们重视。并被广泛应用于病毒、癌症等重大疾病的筛查与治疗研究中。新兴循环生物标记物的应用与开发,在HBV、HPV的检测和肿瘤的靶向药物治疗、细胞治疗、免疫抑制剂、癌症疫苗开发方向上都取得了重大成果。与传统的医疗方法相比,生物标记物为辅助精准医疗的检测治疗模式,无论是在研发还是治疗上都有着显著的优势。因此,综述了生物标记物与精准医疗的应用,并就最近的研究报告重点综述了生物标记物与精准医疗的最新研究进展。

关 键 词:精准医疗  生物标记物  癌症疫苗  靶向药物  
收稿时间:2019-01-10

Reserch Progress on Biomarkers and Precision Medicine
Xi-wen JIANG,Zi-wei DONG,Yue LIU,Xiao-ya ZHU.Reserch Progress on Biomarkers and Precision Medicine[J].China Biotechnology,2019,39(2):74-81.
Authors:Xi-wen JIANG  Zi-wei DONG  Yue LIU  Xiao-ya ZHU
Abstract:Since the concept of precision medicine was proposed in 2015, more and more attention has been paid to biomarkers and precision medicine. Biomarkers is widely used in the screening and treatment of major diseases such as virus and cancer. The application and development of new circulating biomarkers have made great achievements in the development of HBV, HPV detection and tumor targeted drug therapy, cell therapy, immunosuppressant and cancer vaccine. Compared with traditional medical methods, biomarkers have significant advantages in both research and development and in the treatment of detection and treatment mode assisted by precision medicine. Therefore, this paper reviews the application of biomarkers and precision medicine, and focuses on the latest research progress of biomarkers and precision medicine in recent research reports.
Keywords:Precision medicine  Biomarkers  Cancer vaccine  Targeted drugs  
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