慢性肝病发展中肠道菌群参与调控的分子机制

人体肠道内寄生着大量的肠道菌群，它们参与机体多种生命活动，其紊乱被认为与多种疾病密切相关。肝与肠道之间存在着特殊的解剖位置关系，二者相互作用，相互影响。肠道菌群通过肠-肝轴参与一系列生理病理反应，最终影响慢性肝疾病的发展。目前，有众多学者对肠道菌群在肝疾病中的作用进行了研究，但涉及其中具体的机制尚未探明。本文就肠道菌群通过参与Toll样受体(TLRs)活化加重肝纤维化；胆汁酸代谢调控非酒精性脂肪性肝病（NAFLD）；T细胞分化改善酒精性肝病（ALD)；活性氧簇(ROS)生成影响肝癌(HCC)发展中的具体分子机制做一综述。

Molecular Mechanism of Intestinal Flora Involved in the Development of Chronic Liver Disease

As the largest microbial community in human body, gut microbiota are involved in various life activities of the body. Its dysbiosis was considered to be closely related to a variety of diseases. There was a special anatomical relationship and mutual effect between the liver and the intestine tract. Gut microbiota was involved in multiple pathways through the gut-liver axis, affecting the progression of liver disease. At present, many scholars have studied the role of gut microbiota in chronic liver diseases. This article reviews the specific molecular mechanisms of intestinal flora in participating in Toll-like receptors (TLRs) activation to aggravate liver fibrosis, regulating bile acid metabolism in nonalcoholic fatty liver disease (NAFLD), modulating T cell differentiation to improve alcoholic liver disease (ALD), and controlling reactive oxygen species (ROS) generation to affect hepatocellular carcinoma (HCC) development.